Relationship between CIP2A expression, and prognosis and MDR-related proteins in patients with advanced gastric cancer

International Journal of Clinical and Experimental Pathology

Jian-Shi Chen¹ 

关键词: Gastric cancer;    CIP2A;    p53;    Helicobacter pylori;    MRD;    survival time;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

CIP2A is highly expressed in a variety of malignancies. We determined the expression and clinical significance of CIP2A in patients with advanced gastric cancer. CIP2A protein was expressed in 25 of 37 cancer tissue specimens. There was no correlation between CIP2A and PGP, GST-π, Topo-II, and LRP expression. Survival analysis showed significant differences between the survival rate of the CIP2A protein-positive and -negative groups (χ2=4.509, P=0.034), but the degree of positive expression was unrelated to survival time (χ2=4.639, P=0.098). CIP2A expression may have no prospective value for optimizing chemotherapy regimens, but it can be an indicator for patient prognosis.

【 授权许可】

CC BY-NC