Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
Mechanisms controlling Th17 cytokine expression and host defense | |
关键词: IL‐; 17; IL‐; 22; STAT3; segmented filamentous bacteria; aryl hydrocarbon receptor; | |
DOI : 10.1189/jlb.0211099 | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
Th17cellscontributetomucosalimmunitybystimulatingepithelialcellstoinduceantimicrobialpeptides,granulopoiesis,neutrophilrecruitment,andtissuerepair.RecentstudieshaveidentifiedimportantrolesforcommensalmicrobiotaandAhrligandsinstabilizingTh17geneexpressioninvivo,linkingenvironmentalcuestoCD4Tcellpolarization.EpigeneticchangesthatoccurduringthetransitionfromnaïvetoeffectorTh17cellsincreasetheaccessibilityofil17a,il17f,andil22locitotranscriptionfactors.Inaddition,Th17cellsmaintainthepotentialforexpressingT‐bet,Foxp3,orGATA‐bindingprotein‐3,explainingtheirplasticnatureundervariouscytokinemicroenvironments.AlthoughCD4TcellsaremajorsourcesofIL‐17andIL‐22,innatecellpopulations,includingγδTcells,NKcells,andlymphoidtissue‐inducercells,areearlysourcesofthesecytokinesduringIL‐23‐drivenresponses.EpithelialcellsandfibroblastsareimportantcellulartargetsforIL‐17invivo;however,recentdatasuggestthatmacrophagesandBcellsarealsostimulateddirectlybyIL‐17.Thus,Th17cellsinteractwithmultiplepopulationstofacilitateprotectionagainstintracellularandextracellularpathogens...
【 授权许可】
CC BY
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