Mechanisms controlling Th17 cytokine expression and host defense

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: IL‐;    17;    IL‐;    22;    STAT3;    segmented filamentous bacteria;    aryl hydrocarbon receptor;   

DOI  :  10.1189/jlb.0211099

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Th17cellscontributetomucosalimmunitybystimulatingepithelialcellstoinduceantimicrobialpeptides,granulopoiesis,neutrophilrecruitment,andtissuerepair.RecentstudieshaveidentifiedimportantrolesforcommensalmicrobiotaandAhrligandsinstabilizingTh17geneexpressioninvivo,linkingenvironmentalcuestoCD4Tcellpolarization.EpigeneticchangesthatoccurduringthetransitionfromnaïvetoeffectorTh17cellsincreasetheaccessibilityofil17a,il17f,andil22locitotranscriptionfactors.Inaddition,Th17cellsmaintainthepotentialforexpressingT‐bet,Foxp3,orGATA‐bindingprotein‐3,explainingtheirplasticnatureundervariouscytokinemicroenvironments.AlthoughCD4TcellsaremajorsourcesofIL‐17andIL‐22,innatecellpopulations,includingγδTcells,NKcells,andlymphoidtissue‐inducercells,areearlysourcesofthesecytokinesduringIL‐23‐drivenresponses.EpithelialcellsandfibroblastsareimportantcellulartargetsforIL‐17invivo;however,recentdatasuggestthatmacrophagesandBcellsarealsostimulateddirectlybyIL‐17.Thus,Th17cellsinteractwithmultiplepopulationstofacilitateprotectionagainstintracellularandextracellularpathogens...

【 授权许可】

CC BY