Th17 cells: critical mediators of host responses to burn injury and sepsis

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: IL‐;    17;    IL‐;    22;    ROR‐;    γ;    t;    aryl hydrocarbon receptor;   

DOI  :  10.1189/jlb.0212083

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Thcellshavelongbeenrecognizedasvitalcomponentsoftheadaptiveimmunesystem.Untilrecently,CD3+CD4+Thcellsweredividedintocell‐mediatedTh1orhumoralTh2responses.However,theTh1‐Th2hypothesisfailedtoaccommodatethemorerecentlydescribedTh17cells.Today,themajorThcellsubsetsincludeTh1,Th2,Th9,Th17,Th22,andTregs,eachofwhichproducespecificeffectorcytokinesunderuniquetranscriptionalregulation.Specifically,Th17cellsproduceeffectorcytokinesIL‐17,IL‐21,andIL‐22undertheregulationofROR‐γt.Th17lymphocyteswerefirstdescribedasorchestratorsofneutrophilrecruitmentandactivationandaskeyplayersinchronicinflammationandautoimmunity.MorerecentevidencesuggestthatTh17lymphocytesandtheireffectorcytokinesplayacrucialroleinmaintainingmucosalimmunityandbarrierintegrity,includingtheskin,lung,andgut.Burninjuryinducesglobalchangestothesystemicimmuneresponse,includingsuppressedimmunefunctionandincreasedsusceptibilitytoinfection.Moreover,burntraumaisassociatedwithremoteorganinjury.Thisrelationshipbetweenburnandremoteorganinjurysupportsthehypothesisthatimmunesuppressionmayfacilitatethedevelopmentofsepsis,systemicinflammatoryresponsesyndrome,andmultipleorgandysfunctionsyndromeincriticallyillburnpatients.Herein,wediscussthisemergingadaptivecellsubsetincriticalcaresettings,includingburninjuryandclinicalsepsis,andhighlightthepotentialtherapeuticroleofIL‐22...

【 授权许可】

CC BY