| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Nicotine induces neutrophil extracellular traps | |
| 关键词: tobacco; protein kinase B; ROS; nicotinic acetylcholine receptor; | |
| DOI : 10.1189/jlb.3AB0815-379RR | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
NETsservetoensnareandkillmicrobialpathogens.However,NETscanatthesametimecontributetotissuedamageandexcessiveinflammation.Nicotineisamajortoxicagentandhasbeenassociatedwithexacerbatedinflammatorydiseases.Thecurrentstudyaimedatinvestigatingtheroleofnicotine,theaddictivecomponentoftobaccoandelectroniccigarettes,ontriggeringNETformation.WereportthatnicotineinducesneutrophilstoreleaseNETsinadose‐dependentmanner.Nicotine‐inducedNETformationismediatedvianicotineacetylcholinereceptors,dependsonAktandPAD4activation,butisNox2‐independent,asdemonstratedbypharmacologicalinhibitionofNox2andbyuseofNox2‐deficientmouseneutrophils.ThesefindingsdemonstratethatnicotineinducesNETs,whichmayinturncontributetosmoking‐relateddiseases...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901237976159ZK.pdf | 1179KB |  download |
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