| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Role of the reprogramming factor KLF4 in blood formation | |
| 关键词: transcription factor; hematopoiesis; gene regulation; lymphocytes; myeloid cells; | |
| DOI : 10.1189/jlb.1RU1215-539R | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
 PDF
|
|
【 摘 要 】
Krüppel‐likefactor4isazincfingerproteinwithdualfunctionsthatcanactasatranscriptionalactivatorandrepressorofgenesinvolvedincellproliferation,differentiation,andapoptosis.Althoughmoststudieshavefocusedonterminallydifferentiatedepithelialcells,evidencesuggeststhatKrüppel‐likefactor4regulatesthedevelopmentandfunctionofthemyeloidandlymphoidbloodlineages.TheabilityofKrüppel‐likefactor4todedifferentiatefromsomaticcellsintopluripotentstemcellsincooperationwithotherreprogrammingfactorssuggestsitspotentialfunctioninthepreservationoftissue‐specificstemcells.Additionally,emerginginterestintheredifferentiationofinducedpluripotentstemcellsintobloodcellstocorrecthematologicdeficienciesandmalignancieswarrantsfurtherstudiesontheroleofKrüppel‐likefactor4insteady‐statebloodformation...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901237489729ZK.pdf | 1294KB |  download |
878987797
028-85220240
