期刊论文详细信息
Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
Role of the reprogramming factor KLF4 in blood formation | |
关键词: transcription factor; hematopoiesis; gene regulation; lymphocytes; myeloid cells; | |
DOI : 10.1189/jlb.1RU1215-539R | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
Krüppel‐likefactor4isazincfingerproteinwithdualfunctionsthatcanactasatranscriptionalactivatorandrepressorofgenesinvolvedincellproliferation,differentiation,andapoptosis.Althoughmoststudieshavefocusedonterminallydifferentiatedepithelialcells,evidencesuggeststhatKrüppel‐likefactor4regulatesthedevelopmentandfunctionofthemyeloidandlymphoidbloodlineages.TheabilityofKrüppel‐likefactor4todedifferentiatefromsomaticcellsintopluripotentstemcellsincooperationwithotherreprogrammingfactorssuggestsitspotentialfunctioninthepreservationoftissue‐specificstemcells.Additionally,emerginginterestintheredifferentiationofinducedpluripotentstemcellsintobloodcellstocorrecthematologicdeficienciesandmalignancieswarrantsfurtherstudiesontheroleofKrüppel‐likefactor4insteady‐statebloodformation...【 授权许可】
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