| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Caspase‐1 as a multifunctional inflammatory mediator: noncytokine maturation roles | |
| 关键词: inflammasomes; pyroptosis; caspase‐; 11; | |
| DOI : 10.1189/jlb.3MR0516-224R | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
 PDF
|
|
【 摘 要 】
Caspase‐1isaninflammatorycaspasethatisactivatedthroughformationofinflammasomecomplexesinresponsetobothpathogen‐derivedandendogenousmediators.Themostwell‐knownfunctionofactivecaspase‐1istocleavetheproformsofinflammatorycytokinesIL‐1βand‐18intotheiractiveformsinresponsetoinflammatorystimuliinimmunecells.However,recentevidencesuggeststhatcaspase‐1hasmultiplefunctionsinadditiontothiscytokinematurationroleandthatitisatthecenterofmanycellresponsestostressandinflammation.Thecurrentreviewfocusesonrolesforcaspase‐1,andthecloselyrelatedcaspase‐11,ininflammatoryformsofcelldeathandproteincleavageandalsoinproteinsecretion.Thesealternativecaspase‐1functionscaninfluenceinflammatoryresponses,notjustinimmunecellsbutinothercelltypes,suchasepithelia,whereinflammatorycytokineproductionmaynotbeaprimarycellfunction...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901236276073ZK.pdf | 617KB |  download |
878987797
028-85220240
