| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Type 2 innate lymphoid cells constitutively express arginase‐I in the naïve and inflamed lung | |
| 关键词: ILC2; Yarg; Arg1‐; YFP; Nippostrongylus brasiliensis ; alternatively activated macrophages; | |
| DOI : 10.1189/jlb.0213084 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Arg1isproducedbyAAMsandisproposedtohavearegulatoryroleduringasthmaandallergicinflammation.Here,weuseanArg1reportermousetoidentifyadditionalcellularsourcesoftheenzymeinthelung.WedemonstratethatILC2sexpressArg1atrestandduringinfectionwiththemigratoryhelminthNippostrongylusbrasiliensis.IncontrasttoAAMs,whichexpressArg1followingIL‐4/IL‐13‐mediatedSTAT6activation,ILC2sconstitutivelyexpresstheenzymeinaSTAT6‐independentmanner.AlthoughILC2sdeficientintheIL‐33RsubunitT1/ST2maintainArg1expression,IL‐33canregulatetotallungArg1byexpandingtheILC2populationandbyactivatingmacrophagesindirectlyviaSTAT6.Finally,wefindthatILC2Arg1doesnotmediateILC2accumulation,ILC2productionofIL‐5andIL‐13,orcollagenproductionduringN.brasiliensisinfection.Thus,ILC2sareanovelsourceofArg1inrestingtissueandduringallergicinflammation...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901235742533ZK.pdf | 1004KB |  download |
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