Redox stress unbalances the inflammatory cytokine network: role in autoinflammatory patients and healthy subjects

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: interleukin‐;    1 family;    ATP secretion;    TLR agonist;    NLRP3 inflammasome;   

DOI  :  10.1189/jlb.3MR0415-159R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Thecellstressandredoxresponsesareincreasinglyacknowledgedasfactorscontributingtothegenerationanddevelopmentoftheinflammatoryresponse.Severalinflammation‐inducingstressorshavebeenidentified,insideandoutsideofthecell.Furthermore,manyhereditarydiseasesassociatewithinflammationandoxidativestress,suggestingaroleformutatedproteinsasstressors.Thenucleotide‐bindingoligomerizationdomain,leucine‐richrepeat‐containingfamily,pyrindomain‐containing3(NLRP3)inflammasomeisanimportantnodeatthecrossroadbetweenredoxresponseandinflammation.Remarkably,monocytesfrompatientswithmutationsintheNLRP3geneundergooxidativestressafterstimulationwithminuteamountsofTLRagonists,resultinginunbalancedproductionofIL‐1βandregulatorycytokines.SimilaralterationsincytokineproductionarefoundinhealthymonocytesuponTLRoverstimulation.Thismini‐reviewsummarizesrecentprogressinthisfield,discussesthemolecularmechanismsunderlyingthelossofcontrolofthecytokinenetworkfollowingoxidativestress,andproposesnewtherapeuticopportunities...

【 授权许可】

CC BY