| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| New development in studies of formyl‐peptide receptors: critical roles in host defense | |
| 关键词: leukocytes; trafficking; inflammation; immunity; cancer; | |
| DOI : 10.1189/jlb.2RI0815-354RR | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Formyl‐peptidereceptorsareafamilyof7transmembranedomain,Gi‐protein‐coupledreceptorsthatpossessmultiplefunctionsinmanypathophysiologicprocessesbecauseoftheirexpressioninavarietyofcelltypesandtheircapacitytointeractwithavarietyofstructurallydiverse,chemotacticligands.Accumulatingevidencedemonstratesthatformyl‐peptidereceptorsarecriticalmediatorsofmyeloidcelltraffickinginthesequentialchemotaxissignalrelaysinmicrobialinfection,inflammation,andimmuneresponses.Formyl‐peptidereceptorsarealsoinvolvedinthedevelopmentandprogressionofcancer.Inaddition,oneoftheformyl‐peptidereceptorfamilymembers,Fpr2,isexpressedbynormalmouse‐colonepithelialcells,mediatescellresponsestomicrobialchemotacticagonists,participatesinmucosaldevelopmentandrepair,andprotectsagainstinflammation‐associatedtumorigenesis.Thesenoveldiscoveriesgreatlyexpandedthecurrentunderstandingoftheroleofformyl‐peptidereceptorsinhostdefenseandaspotentialmoleculartargetsforthedevelopmentoftherapeutics...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901235264654ZK.pdf | 1008KB |  download |
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