| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| IL‐10 regulates Aicda expression through miR‐155 | |
| 关键词: TLR4; AID; miRNA; B cell; antibody class‐; switching; interleukin; | |
| DOI : 10.1189/jlb.2A0314-178R | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
 PDF
|
|
【 摘 要 】
Aicdaisacriticalcomponentofantibodyclass‐switchinginBcells.Inthiswork,westudytheimpactofTLR4activationandIL‐10stimulationonAicdaexpressioninBcells.ThroughtheglobalanalysisofmiRNAsinresponsetoTLR4activation,incombinationwithIL‐10stimulation,weidentifiedthatIL‐10cansuppressTLR4‐inducedmiR‐155expression,aneffectthatresultedinenhancedAicdaexpression.Furthermore,whenpreventingmiR‐155controlofAicdaexpression,bygeneticmutationofitstargetsiteintheAicdamRNA,IL‐10couldfurtherpotentiateAicdaexpression.GiventhatmiR‐155expressionislost,andexpressionlevelsofbothAicdaandIL‐10arehighindiseases,suchasBurkitt’slymphoma,ourresultssuggestastringentandsophisticatedcontrolofAicdabyanovelIL‐10/miR‐155axis,wheretheimbalanceofIL‐10and/ormiR‐155maycontributetodiseasepathogenesis...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901234849781ZK.pdf | 1029KB |  download |
878987797
028-85220240
