Toll‐like receptors in the host defense against Pseudomonas aeruginosa respiratory infection and cystic fibrosis

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: MyD88;    TRIF;    MAP kinases;   

DOI  :  10.1189/jlb.0811410

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

TLRsfunctionininnateimmunitybydetectingconservedstructurespresentinbacteria,viruses,andfungi.AlthoughTLRsdonotnecessarilydistinguishpathogenicorganismsfromcommensals,inthecontextofcompromisedinnateimmunityandcombinedwithpathogensˈeffectormolecules,TLRsdrivethehostresponsetotheorganism.Thisreviewwilldiscusstheevidenceandrole(s)ofTLRsintheresponsetotheopportunisticbacterialpathogen,Pseudomonasaeruginosa,asitrelatestorespiratoryinfectionandCF,inwhichinnateimmunemechanismsareindeedcompromised.Outermembranelipoproteins,LPS,flagellin,andnucleicacidsallserveasligandsforTLR2,‐4,‐5,and‐9,respectively.TheseTLRsandtheirrespectivedownstreameffectormoleculeshaveprovencriticaltothehostresponsetoP.aeruginosa,althoughtheprotectiveeffectsofTLRsmaybeimpairedandinsomecases,enhancedintheCFpatient,contributingtotheparticularsusceptibilityofindividualswiththisdiseasetoP.aeruginosainfection...

【 授权许可】

CC BY