Central Pressure and Biomarker Responses to Renin Inhibition with Hydrochlorothiazide and Ramipril in Obese Hypertensives: The ATTAIN Study

Cardiorenal medicine

Adam Whaley-Connell ; Das Purkayastha ; Anthony Yadao ; James R. Sowers

关键词: Aliskiren;    Hydrochlorothiazide;    Obesity;    Plasma renin activity;    Ramipril;    Stage 2 hypertension;   

DOI  :  10.1159/000322864

学科分类：心脏病和心血管学

来源: S Karger AG

【 摘 要 】

Abstract Background/Aims: In obese, hypertensive subjects, the renin-angiotensin system (RAS) is enhanced and natriuresis impaired, suggesting a role for combination RAS blockade with diuretics. Data suggest that renin inhibition may attenuate diuretic-induced RAS activation and oxidative stress. Methods: In this 8-week, double-blind study of 386 obese individuals (mean body mass index: 35.3) with stage 2 hypertension (mean age: 54.9 years; mean sitting systolic blood pressure, SBP: 6160 but !20.

【 授权许可】

CC BY