Donor‐ but not host‐derived interleukin‐10 contributes to the regulation of experimental graft‐versus‐host disease

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: cytokines;    IL‐;    10;    BMT;    GVHD;    Tregs;   

DOI  :  10.1189/jlb.1011510

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

IL‐10isakeyimmune‐regulatorycytokine,anditsgenepolymorphismscorrelatewithseverityofclinicalGVHD.IL‐10ismadebyavarietyofdonorandhostcells,butthefunctionalrelevanceofitssourceanditsroleinthebiologyofacuteGVHDarenotwellunderstood.WeusedpreclinicalmodelstoexaminetherelevanceofIL‐10−/−indonorandhostcellularsubsetsontheseverityofGVHD.IL‐10−/−inhosttissuesorinthedonorgraftsdidnotalterdonorTeff‐mediatedseverityofGVHD.Furthermore,neitherhost‐derivednordonorTeff‐derivedIL‐10wasrequiredforregulationofGVHDbyWTCD4+CD25+donorTregs.Bycontrast,Treg‐derivedIL‐10,althoughnotobligatory,wasnecessaryforoptimalreductionofGVHDbymaturedonorTregs.Importantly,IL‐10fromdonorBMgraftswasalsocriticalforoptimaldonorTreg‐mediatedsuppressionofGVHD.Together,thesedatasuggestthatIL‐10doesnotcontributetotheinductionofGVHDseveritybytheTeffs.However,donorBMgraftandTreg‐derivedIL‐10areimportantfordonorTreg‐mediatedsuppressionofGVHD...

【 授权许可】

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