Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
Donor‐ but not host‐derived interleukin‐10 contributes to the regulation of experimental graft‐versus‐host disease | |
关键词: cytokines; IL‐; 10; BMT; GVHD; Tregs; | |
DOI : 10.1189/jlb.1011510 | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
IL‐10isakeyimmune‐regulatorycytokine,anditsgenepolymorphismscorrelatewithseverityofclinicalGVHD.IL‐10ismadebyavarietyofdonorandhostcells,butthefunctionalrelevanceofitssourceanditsroleinthebiologyofacuteGVHDarenotwellunderstood.WeusedpreclinicalmodelstoexaminetherelevanceofIL‐10−/−indonorandhostcellularsubsetsontheseverityofGVHD.IL‐10−/−inhosttissuesorinthedonorgraftsdidnotalterdonorTeff‐mediatedseverityofGVHD.Furthermore,neitherhost‐derivednordonorTeff‐derivedIL‐10wasrequiredforregulationofGVHDbyWTCD4+CD25+donorTregs.Bycontrast,Treg‐derivedIL‐10,althoughnotobligatory,wasnecessaryforoptimalreductionofGVHDbymaturedonorTregs.Importantly,IL‐10fromdonorBMgraftswasalsocriticalforoptimaldonorTreg‐mediatedsuppressionofGVHD.Together,thesedatasuggestthatIL‐10doesnotcontributetotheinductionofGVHDseveritybytheTeffs.However,donorBMgraftandTreg‐derivedIL‐10areimportantfordonorTreg‐mediatedsuppressionofGVHD...
【 授权许可】
CC BY
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