| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Viral dsRNA‐activated human dendritic cells produce IL‐27, which selectively promotes cytotoxicity in naïve CD8+ T cells | |
| 关键词: BDCA1+ DC; human cytokines; Granzyme B; IFN‐; gamma; Cytotoxic T Lymphocytes; | |
| DOI : 10.1189/jlb.0112045 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
ViralrecognitionprogramsDCstoexpressSignal3moleculesthatpromotethedifferentiationofeffectorCD8+Tcells.BesidesIL‐12,anotherDC‐derivedIL‐12familymember,IL‐27,hasbeenreportedtocontributeherein,butitsspecificroleisnotwellunderstood.Here,weshowthatwhereasIL‐12potentlyinducesinflammatorycytokines(i.e.,IFN‐γandTNF‐α,butnotIL‐2),IL‐27excelsininducingproliferationandacytotoxicprofile(GrB,cytotoxicityoftargetcells)inhumannaïveCD8+Tcells.Comparedwithbacterialcell‐wallpeptidoglycan,viraldsRNA‐mimicpoly(I:C)issuperiorinpriminghumanBDCA1+peripheralbloodDCstoproduceIL‐12andIL‐27,whichpromoteinflammatorycytokinesandacytotoxicprofileindifferentiatingCD8+Tcells,respectively.ThesedatasupporttheconceptthatviraldsRNA‐activatedhumanDCsproduceIL‐27toactasaspecializedprocytotoxic,antiviralcytokineinthedevelopmentofeffectorCD8+Tcells...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901232333211ZK.pdf | 1317KB |  download |
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