| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Recent findings on the role of natural killer cells in the pathogenesis of systemic lupus erythematosus | |
| 关键词: SLE; autoimmunity; MRL/MpJ; PBMC; MRL/MpJlpr; Lupus nephritis; | |
| DOI : 10.1189/jlb.4RU0315-081RR | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Systemiclupuserythematosusisachronic,multifactorialautoimmunediseaseofcomplexetiology,characterizedbylossoftolerancetonuclearautoantigens,expansionofautoreactiveTandBcellclones,polyclonalBcellactivationthatgivesrisetohypergammaglobulinemia,andincreasedautoantibodyproduction,aswellasimmunecomplexdepositionandmultiorgantissueinflammation.Asdiseaseprogresses,immunecells,mainlyTcellsandmacrophages,infiltrateaffectedorgansandamplifythelocalinflammatoryresponse.Naturalkillercellsarelarge,granularlymphocytesthatareanimportantlinkbetweentheinnateandadaptiveimmunesystems;variationsintheiractivitycorrelatewithseveralautoimmunediseases.Todate,theliteraturehasdisregardednaturalkillercellsasrelevantmodulatorsinsystemiclupuserythematosuspathogenesis,asthesecellsarefewinnumberandshowadysfunctionalphenotypeinpatientswithactivesystemiclupuserythematosus.Thisreviewfocusesonresearchthatcouldhelpdefinetheroleofnaturalkillercellsinsystemiclupuserythematosusandtheirfunctioninregulatingthisautoimmunedisorderinnonlymphoidorgans...
【 授权许可】
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【 预 览 】
| Files | Size | Format | View |
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| RO201901231892250ZK.pdf | 707KB |  download |
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