期刊论文详细信息
International Journal of Clinical and Experimental Pathology
Phosphorylated mTOR expression correlates with poor outcome in early-stage triple negative breast carcinomas
Shir-Hwa Ueng1 
关键词: Phosphorylated mammalian target of rapamycin (p-mTOR);    triple negative;    breast cancer;   
DOI  :  
学科分类:生理学与病理学
来源: e-Century Publishing Corporation
PDF
【 摘 要 】

The mammalian target of rapamycin (mTOR) plays an important role in cell growth, proliferation, and metabolism. Some studies have associated phosphorylated mTOR (p-mTOR) expression with worse outcome in breast cancers. However, the significance of p-mTOR expression specifically in triple negative breast carcinoma (TNBC) is unknown. In this study, p-mTOR expression was evaluated by immunohistochemistry in 172 TNBCs and the result was correlated with clinicopathologic variables and disease outcome. The majority of tumors (72.1%) were p-mTOR positive; p-mTOR expression did not correlate with age, tumor size, grade, lymph node status, or tumor stage. In patients at stage 1 and 2 disease, those with p-mTOR expression had significantly worse overall as well as recurrence-free survival compared to those without p-mTOR expression. p-mTOR expression appears to be an adverse prognostic indicator in early-stage TNBCs. The assessment of p-mTOR expression in these tumors may also help to stratify patients for future target therapy studies.

【 授权许可】

CC BY-NC   

【 预 览 】
附件列表
Files Size Format View
RO201901230875440ZK.pdf 916KB PDF download
  文献评价指标  
  下载次数:11次 浏览次数:18次