Tissue plasminogen activator and inflammation: from phenotype to signaling mechanisms

American journal of clinical and experimental immunology

Ling Lin¹ 

关键词: Tissue plasminogen activator;    tPA;    inflammation;    phenotype;    signaling mechanisms;   

DOI  :  

学科分类：过敏症与临床免疫学

来源: e-Century Publishing Corporation

【 摘 要 】

In disease conditions, inflammatory cells, such as neutrophils, T cells, and monocytes/macrophages, are recruited in response to injury cues and express panoply of proinflammatory genes through a combination of transcription factors. Tissue plasminogen activator (tPA), a member of the serine protease family, has been shown to act as cytokine to activate profound receptor-mediated signaling events. In this review, we will discuss the role of tPA in inflammation in various models, and illuminate its signaling mechanisms underlying its modulation of inflammation.

【 授权许可】

CC BY-NC