| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Inhibition of caspase‐8 activity promotes protective Th1‐ and Th2‐mediated immunity to Leishmania major infection | |
| 关键词: apoptosis; CD4 T cells; FasL; FLIP; cytokines; | |
| DOI : 10.1189/jlb.0912463 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
 PDF
|
|
【 摘 要 】
Weinvestigatedhowapoptosispathwaysmediatedbydeathreceptorsandcaspase‐8affectcytokineresponsesandimmunitytoLeishmaniamajorparasites.SplenicCD4Tcellsundergoactivation‐inducedapoptosis,andblockadeofFasL‐FasinteractionincreasedIFN‐γandIL‐4cytokineresponsestoL.majorantigens.Toblockdeathreceptor‐induceddeath,weusedmiceexpressingaTcell‐restrictedtransgeneforvFLIP.Inhibitionofcaspase‐8activationinvFLIPmiceenhancedTh1andTh2cytokineresponsestoL.majorinfection,evenintheTh1‐proneB6background.WealsoobservedincreasedNOproductionbysplenocytesfromvFLIPmiceuponTcellactivation.DespiteanexacerbatedTh2response,vFLIPmicecontrolledbetterL.majorinfection,withreducedlesionsandlowerparasiteloadscomparedwithWTmice.Moreover,injectionofanti‐IL‐4mAbininfectedvFLIPmicedisruptedcontrolofparasiteinfection.Therefore,blockadeofcaspase‐8activityinTcellsimprovesimmunitytoL.majorinfectionbypromotingincreasedTh1andTh2responses...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901230660078ZK.pdf | 1557KB |  download |
878987797
028-85220240
