Mechanisms of resistance of normal cells to TRAIL induced apoptosis vary between different cell types

FEBS Letters

Nguyen, Tam¹  Hersey, Peter¹  Sanders, Jayne E¹  Thomas, Wayne D¹  Zhang, Xu Dong¹ 

[1] The Oncology and Immunology Unit, Newcastle Mater Hospital, David Maddison Building, Room 443, Cnr. King and Watt Streets, Newcastle, N.S.W. 2300, Australia

关键词: TNF related apoptosis inducing ligand;    TNF related apoptosis inducing ligand receptor;    TNF related apoptosis inducing ligand induced apoptosis;    Normal cell;    TNF;    tumour necrosis factor;    TRAIL;    TNF related apoptosis inducing ligand;    FasL;    Fas ligand;    TRAIL-Rs;    TRAIL receptors;    FLIP;    FLICE inhibitory protein;    IAP;    inhibitor of apoptosis protein;    HUVECs;    human umbilical vein endothelial cells;    GPI;    glycosyl phosphatidylinositol;    PI-PLC;    phosphatidylinositol specific phospholipase C;    ER;    endoplasmic reticulum;    WGA lectin;    wheat germ agglutinin;   

DOI  :  10.1016/S0014-5793(00)02042-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Resistance of normal cells to tumour necrosis factor related apoptosis inducing ligand (TRAIL) induced apoptosis is believed to be mediated by expression of two decoy receptors. Here we show that the expression and localisation of TRAIL receptors (TRAIL-Rs) vary between different cells and that resistance to TRAIL is mediated by different mechanisms. The decoy receptor, TRAIL-R3, appeared important in protection of endothelial cells, whereas lack of surface death receptor expression and as yet unknown intracellular inhibitor(s) of apoptosis downstream of caspase-3 may play a major role in protection of melanocytes and fibroblasts from TRAIL induced apoptosis, respectively. Differential subcellular location of decoy receptors may be an important determinant of their effectiveness in different types of normal cells.

【 授权许可】

Unknown