miR-506 inhibits the proliferation and invasion by targeting IGF2BP1 in glioblastoma

American Journal of Translational Research

Yonggang Luo¹ 

关键词: Glioblastoma;    miRNA;    miR-506;    IGF2BP1;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Increasing evidence has indicated that microRNAs (miRNAs) play an essential role in cancers. Deregulation of miR-506 was reported in several cancers. However, the expression and function of miR-506 in glioblastoma remain unclear. Our data showed that the level of miR-506 was downregulated in glioblastoma tissues and cell lines. Overexpression of miR-506 repressed cell growth, blocked G1/S transition, and suppressed cell invasion in glioblastoma cell. Moreover, IGF2BP1 was a direct target of miR-506 in glioblastoma cells. Knockdown of IGF2BP1 recapitulated the anti-proliferative and anti-invasive effects of miR-506, whereas IGF2BP1 overexpression antagonized the tumor-suppressive function of miR-506. Our data showed that miRNA-506 played a tumor suppressor gene role in human glioblastoma by regulating IGF2BP1 gene and might be a new therapeutic target of human glioblastoma.

【 授权许可】

CC BY-NC