Bacterial Microbiome Dynamics in Post Pull-Through Hirschsprung-Associated Enterocolitis (HAEC): An Experimental Study Employing the Endothelin Receptor B-Null Mouse Model

Frontiers in Surgery

Zhi Cheng¹ 

关键词: hirschsprung-associated enterocolitis;    Hirschsprung enterocolitis;    HAEC;    pull-through surgery;    microbiome;    Akkermansia;    bacteroidetes;   

DOI  :  10.3389/fsurg.2018.00030

学科分类：外科医学

来源: Frontiers

【 摘 要 】

PurposeHirschsprung-associated enterocolitis (HAEC) is the most frequent potentially life-threatening complication in children with Hirschsprung disease (HSCR) even after definitive corrective surgery. Mounting evidence suggests that intestinal microbiota likely contribute to the etiology of enterocolitis, so the aim of this study was to use a mouse model of post pull-through HAEC to compare the fecal bacterial communities of animals which developed HAEC to those free of enterocolitis.

【 授权许可】

CC BY