Mechanism Sharing Between Genetic and Gestational Hypoxia-Induced Cardiac Anomalies

Frontiers in Cardiovascular Medicine

Olivia Moumne¹ 

关键词: cardiac anomaly;    gestational hypoxia;    genetic mutation;    mouse models;    nkx2-5;   

DOI  :  10.3389/fcvm.2018.00100

学科分类：心脏病和心血管学

来源: Frontiers

【 摘 要 】

Background: Cardiac development is a dynamic process both temporally and spatially. These complex processes are often disturbed and lead to congenital cardiac anomalies that affect approximately 1% of live births. Disease-causing variants in several genetic loci lead to cardiac anomalies, with variants in transcription factor NKX2-5 gene being one of the largest variants known. Gestational hypoxia, such as seen in high-altitude pregnancy, has been known to affect cardiac development, yet the incidence and underlying mechanisms are largely unknown.

【 授权许可】

CC BY