The angiotensin-converting enzyme inhibitor captopril rescues mice from endotoxin-induced lethal hepatitis:

Innate Immunity

PuGe¹ 

关键词: Hepatitis;    inflammation;    lipopolysaccharide;    angiotensin-converting enzyme inhibitor;    captopril;   

DOI  :  10.1177/1753425916680037

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

The renin–angiotensin system is classically regarded as a crucial regulator of circulatory homeostasis, but recent studies also revealed its pro-inflammatory roles. The beneficial effects of the angiotensin-converting enzyme inhibitor (ACEI) in severe inflammatory injury in the lung and heart have been previously reported, but its potential effects on lethal hepatitis were unknown. In this study, a mouse model with LPS/d-galactosamine (GalN)-induced fulminant hepatitis were used to test the protective potential of captopril, a representative ACEI. The results indicated that treatment with captopril significantly decreased the plasma level of alanine aminotransferase and aspartate aminotransferase, alleviated the histopathological damage of the liver tissue and improve the survival rate of LPS/GalN-challenged mice. These effects were accompanied by reduced mRNA levels of TNF-α and IL-6 in the liver, and decreased protein level of TNF-α and IL-6 in the plasma. In addition, the activation of caspases 3, 8 an...

【 授权许可】

CC BY