Low serum mannose-binding lectin level is not associated with disease severity in non-cystic fibrosis bronchiectasis:

Innate Immunity

James GMacfarlane¹ 

关键词: Bronchiectasis;    mannose-binding lectin;    Pseudomonas aeruginosa;    infection;    immunity;   

DOI  :  10.1177/1753425912440472

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Deficiency of mannose-binding lectin (MBL), a serum protein involved in killing and promoting phagocytosis of pathogens, is associated with respiratory infection and disease progression in a number of acute and chronic lung diseases, including cystic fibrosis (CF)- associated bronchiectasis. No such association has been studied in non-CF bronchiectasis (nCF-Br). One hundred and thirty-three adult patients with nCF-Br were studied. Serum MBL levels were measured and deficiency defined using two cut-off levels, i.e. MBL ≤100 ng/ml and ≤600 ng/ml. Parameters of severity included lung function impairment, annual exacerbation and hospital admission rates, breathlessness, and Pseudomonas aeruginosa and Haemophilus influenzae infection rates. The incidence of MBL deficiency using cut-off levels of 100 ng/ml and 600 ng/ml was 10% and 26% respectively, similar to rates seen in the general population. There was no significant difference in mean FEV1% predicted between MBL deficient and sufficient patients at both c...

【 授权许可】

CC BY