Early-Life Pseudomonas aeruginosa Infection in Cystic Fibrosis and Lung Disease Progression:

Global Pediatric Health

ArgyriPetrocheilou¹ 

关键词: cystic fibrosis;    lung function;    chest CT scan;    BMI;    Pseudomonas aeruginosa;    infection;   

DOI  :  10.1177/2333794X17738465

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Lung disease in cystic fibrosis (CF) starts early, with studies identifying abnormalities on chest computed tomography (CT) scan even in infancy. In this retrospective study, abnormal chest CT was the main outcome; body mass index (BMI) z score and forced expiratory volume percent predicted (FEV1%) predicted at age 6 to 7 years were secondary outcomes. Pseudomonas aeruginosa infection prior to 12 months of age was the main explanatory variable. There was no association between early P aeruginosa infection and abnormal CT after adjustment for CFTR (cystic fibrosis transmembrane conductance regulator) functional mutation class, gender, and other pathogens (odds ratio = 0.30; 95% confidence interval = 0.07-1.35; P = .11). No significant associations were demonstrated for BMI z score and FEV1% predicted. Children with class I-III CFTR mutations had increased risk of abnormal CT findings (odds ratio = 11.67; 95% confidence interval = 1.11-115.06; P = .035) and lower FEV1% predicted (P = .04). In the current er...

【 授权许可】

CC BY