Cigarette smoke induces growth differentiation factor 15 production in human lung epithelial cells: Implication in mucin over-expression:

Innate Immunity

QunWu¹ 

关键词: Airway epithelial cells;    cigarette smoke;    GDF15;    MUC5AC;   

DOI  :  10.1177/1753425911429837

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Excessive mucus is a hallmark of chronic obstructive pulmonary disease (COPD). There is an emerging interest in the role of TGF-β signaling in the initiation and progression of COPD. Growth differentiation factor 15 (GDF15) is a divergent member of TGF-β superfamily. However, whether cigarette smoke induces airway epithelial GDF15 production and its functions in the airways have not been revealed. Therefore, we first analyzed GDF15 protein expression in airway epithelium of human COPD smokers versus normal non-smokers. We then examined the regulation and function of GDF15 in human airway epithelial cells in response to cigarette smoke exposure. We found increased GDF15 protein expression in airway epithelium (mainly in ciliated cells) of human COPD smokers compared with normal non-smokers. Furthermore, cigarette smoke exposure consistently up-regulated GDF15 expression in human airway epithelial cells. Moreover, GDF15 was shown to play a critical role in cigarette smoke-induced airway epithelial MUC5AC ex...

【 授权许可】

CC BY