Lipid metabolism reprogramming and its potential targets in cancer

Cancer Communications

Deliang Guo¹  Xiang Cheng¹  Chunming Cheng¹  Feng Geng¹ 

[1] Department of Radiation Oncology, The Ohio State University James Comprehensive Cancer Center and College of Medicine, Columbus, USA

关键词: Lipid metabolism;    Cancer;    SCAP;    SREBPs;    Fatty acids;    Cholesterol;    Lipid droplets;   

DOI  :  10.1186/s40880-018-0301-4

学科分类：肿瘤学

来源: Springer

【 摘 要 】

Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy. Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute to rapid tumor growth. Lipids constitute the basic structure of membranes and also function as signaling molecules and energy sources. Sterol regulatory element-binding proteins (SREBPs), a family of membrane-bound transcription factors in the endoplasmic reticulum, play a central role in the regulation of lipid metabolism. Recent studies have revealed that SREBPs are highly up-regulated in various cancers and promote tumor growth. SREBP cleavage-activating protein is a key transporter in the trafficking and activation of SREBPs as well as a critical glucose sensor, thus linking glucose metabolism and de novo lipid synthesis. Targeting altered lipid metabolic pathways has become a promising anti-cancer strategy. This review summarizes recent progress in our understanding of lipid metabolism regulation in malignancy, and highlights potential molecular targets and their inhibitors for cancer treatment.

【 授权许可】

CC BY