The male excess in sudden infant deaths:

Innate Immunity

Sophia MMoscovis¹ 

关键词: Lipopolysaccharides;    cigarette smoke;    cytokines;    sudden infant death;    testosterone;   

DOI  :  10.1177/1753425913481071

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

The peak age at which sudden infant death syndrome (SIDS) occurs corresponds to the developmental period in which infants are dependent on their innate responses to infection. There is a growing body of evidence indicating that dysregulation of inflammatory responses might contribute to the physiological changes leading to these sudden deaths. This study examined the effects of three important risk factors for SIDS on inflammatory responses: cigarette smoke, virus infection and male sex. Cytokine responses of peripheral monocytic blood cells of healthy, non-smoking males and females to endotoxin were measured. Surrogates for virus infection or cigarette smoke were assessed using IFN-γ or water-soluble cigarette smoke extract (CSE). For most conditions, cells from males had lower pro-inflammatory cytokine responses than those of females. An opposite trend was observed for IL-10. Significantly lower levels of some cytokines were noted for cells from male donors exposed to CSE. In females, there were signifi...

【 授权许可】

CC BY