Immunomodulatory properties of medicinal mushrooms: differential effects of water and ethanol extracts on NK cell-mediated cytotoxicity:

Innate Immunity

Chia-ChenLu¹ 

关键词: Agaricus blazei Murrill;    Antrodia cinnamomea;    caterpillar fungus;    extraction;    Ganoderma lucidum;    Hirsutella sinensis;    immunomodulatory effects;    innate immunity;    medicinal mushrooms;    Ophiocordyceps sinensis;   

DOI  :  10.1177/1753425916661402

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Medicinal mushrooms have been used for centuries in Asian countries owing to their beneficial effects on health and longevity. Previous studies have reported that a single medicinal mushroom may produce both stimulatory and inhibitory effects on immune cells, depending on conditions, but the factors responsible for this apparent dichotomy remain obscure. We show here that water and ethanol extracts of cultured mycelium from various species (Agaricus blazei Murrill, Antrodia cinnamomea, Ganoderma lucidum and Hirsutella sinensis) produce opposite effects on NK cells. Water extracts enhance NK cell cytotoxic activity against cancer cells, whereas ethanol extracts inhibit cytotoxicity. Water extracts stimulate the expression and production of cytolytic proteins (perforin and granulysin) and NKG2D/NCR cell surface receptors, and activate intracellular signaling kinases (ERK, JNK and p38). In contrast, ethanol extracts inhibit expression of cytolytic and cell surface receptors. Our results suggest that the mode...

【 授权许可】

CC BY