Hyperferritinemic Sepsis: An Opportunity for Earlier Diagnosis and Intervention?

Frontiers in Pediatrics

E. Scott Halstead¹ 

关键词: sepsis;    hemophagocytic lymphohistiocytosis;    macrophage activation syndrome;    HSV;    ferritin;    cytokine storm;   

DOI  :  10.3389/fped.2016.00077

学科分类：儿科学

来源: Frontiers

【 摘 要 】

We describe a case of an infant with HSV meningitis and septic shock who demonstrated a remarkably high serum ferritin level. Aggressive pediatric intensive care and the administration of high-dose glucocorticoids were not able to reverse the multiple organ dysfunctions. Subsequent autopsy identified the presence of hemophagocytosis, thus the patient fulfilled hemophagocytic lymphohistiocytosis (HLH) criteria post-mortem. This case highlights that serum ferritin may be an important early indicator of mortality in sepsis due to a cytokine storm similar to macrophage activation syndrome and HLH.

【 授权许可】

CC BY