When and how NK cell-induced programmed cell death benefits immunological protection against intracellular pathogen infection:

Innate Immunity

José EBelizário¹ 

关键词: Apoptosis;    inflammasomes;    NK cells;    necroptosis;    pyroptosis;   

DOI  :  10.1177/1753425918800200

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

NK cells are innate lymphoid cells that exert a key role in immune surveillance through the recognition and elimination of transformed cells and viral, bacterial, and protozoan pathogen-infected cells without prior sensitization. Elucidating when and how NK cell-induced intracellular microbial cell death functions in the resolution of infection and host inflammation has been an important topic of investigation. NK cell activation requires the engagement of specific activating, co-stimulatory, and inhibitory receptors which control positively and negatively their differentiation, memory, and exhaustion. NK cells secrete diverse cytokines, including IFN-γ, TNF-α/β, CD95/FasL, and TRAIL, as well as cytoplasmic cytotoxic granules containing perforin, granulysin, and granzymes A and B. Paradoxically, NK cells also kill other immune cells like macrophages, dendritic cells, and hyper-activated T cells, thus turning off self-immune reactions. Here we first provide an overview of NK cell biology, and then we descr...

【 授权许可】

CC BY