Innate Immunity | |
Identification of putative innate immune related genes from a cell line of the mosquito Aedes albopictus following bacterial challenge: | |
RajnikantDixit1  | |
关键词: Aedes albopictus; innate immunity; subtractive hybridization; mosquito; ESTs; | |
DOI : 10.1177/1753425909350484 | |
学科分类:生物科学(综合) | |
来源: Sage Journals | |
【 摘 要 】
We report identification of putative innate immune related genes from a cell line of the mosquito Aedes albopictus challenged with heat-killed bacteria. Using a subtractive hybridization and sequencing approach, we analyzed a total 309 expressed sequence tags (ESTs) which clustered in 40 contigs. Thirty-five percent of genes yielded homology to known immune genes corresponding to antimicrobial peptides (AMPs), pathogen-associated molecular patterns, protease and immune signaling cascades. Interestingly, most of the genes have not been previously described from this mosquito and thus represent a class of novel immune genes. Further, 25% sequences did not match to any known species in the non-redundant databases, appear to be specific to the mosquito A. albopictus and merit further study.
【 授权许可】
CC BY
【 预 览 】
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RO201901225686195ZK.pdf | 663KB | download |