Vascular endothelial cell Toll-like receptor pathways in sepsis:

Innate Immunity

SamiraKhakpour¹ 

关键词: Endothelial cells;    inflammation;    innate immunity;    sepsis;    Toll-like receptors;   

DOI  :  10.1177/1753425915606525

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

The endothelium forms a vast network that dynamically regulates vascular barrier function, coagulation pathways and vasomotor tone. Microvascular endothelial cells are uniquely situated to play key roles during infection and injury, owing to their widespread distribution throughout the body and their constant interaction with circulating blood. While not viewed as classical immune cells, endothelial cells express innate immune receptors, including the Toll-like receptors (TLRs), which activate intracellular inflammatory pathways mediated through NF-κB and the MAP kinases. TLR agonists, including LPS and bacterial lipopeptides, directly upregulate microvascular endothelial cell expression of inflammatory mediators. Intriguingly, TLR activation also modulates microvascular endothelial cell permeability and the expression of coagulation pathway intermediaries. Microvascular thrombi have been hypothesized to trap microorganisms thereby limiting the spread of infection. However, dysregulated activation of endo...

【 授权许可】

CC BY