Pathophysiological Mechanisms in Sclerosing Skin Diseases

Frontiers in Medicine

Beate Eckes¹ 

关键词: systemic sclerosis;    scleromyxedema;    scleredema;    stiff skin syndrome;    nephrogenic systemic fibrosis;    extracellular matrix;    growth factor activation;   

DOI  :  10.3389/fmed.2017.00120

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

Sclerosing skin diseases represent a large number of distinct disease entities, which include systemic sclerosis, localized scleroderma, and scleredema adultorum. These pathologies have a common clinical appearance and share histological features. However, the specific interplay between cytokines and growth factors, which activate different mesenchymal cell populations and production of different extracellular matrix components, determines the biomechanical properties of the skin and the clinical features of each disease. A better understanding of the mechanisms underlying these events is prerequisite for developing novel targeted therapeutic approaches.

【 授权许可】

CC BY