Immunologic and nonimmunologic sclerodermal skin conditions - review

Frontiers in Immunology

Immunology

Claudiu Ionut Vasile¹  Elena-Laura Parapiru¹  Mihaela Debita¹  Gabriela Balan²  Carmen Tiutiuca³  Carmen Bobeica⁴  Magdalena Miulescu⁴  Elena Niculet⁵  Mihaela Craescu⁵  Ana Maria Pelin⁶  Andreea Mioara Corduneanu-Luca⁷  Alin Codrut Nicolescu⁸  Alin Laurentiu Tatu⁹ 

[1] Clinical Medical Department, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galaţi, Romania;Clinical Medical Department, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galaţi, Romania;Research Center in the Field of Medical and Pharmaceutical Sciences, “Dunărea de Jos” University, Galaţi, Romania;Clinical Surgical Department, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galaţi, Romania;Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galaţi, Romania;Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galaţi, Romania;Multidisciplinary Integrated Center of Dermatological Interface Research MIC-DIR (Centrul Integrat Multidisciplinar de Cercetare de Interfata Dermatologica - CIM-CID), “Dunărea de Jos” University, Galaţi, Romania;Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galaţi, Romania;Department of Plastic Surgery, “Sf. Ioan” Clinical Emergency Hospital for Children, Galaţi, Romania;Dermatology Department “Agrippa Ionescu” Emergency Clinical Hospital, Bucharest, Romania;Multidisciplinary Integrated Center of Dermatological Interface Research MIC-DIR (Centrul Integrat Multidisciplinar de Cercetare de Interfata Dermatologica - CIM-CID), “Dunărea de Jos” University, Galaţi, Romania;Clinical Medical Department, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galaţi, Romania;Dermatology Department, “Sf. Cuvioasa Parascheva” Clinical Hospital of Infectious Diseases, Galaţi, Romania;

关键词: immunological skin conditions;    lichen sclerosus (balanitis xerotica obliterans);    scleroatrophic lichen;    systemic sclerosis;    scleromyxedema;    scleredema Burschke;   

DOI  :  10.3389/fimmu.2023.1180221

 received in 2023-03-05, accepted in 2023-05-16,  发布年份 2023

来源: Frontiers

【 摘 要 】

Scleroderma-like cutaneous lesions have been found in many pathological conditions and they have the clinical appearance of sclerotic or scleroatrophic lesions. Affected skin biopsies described histopathological changes similar to those of scleroderma located strictly on the skin or those of systemic sclerosis. These skin lesions can be found in inflammatory diseases with autoimmune substrate (generalized morphea, chronic graft versus host disease, eosinophilic fasciitis), tissue storage diseases (scleredema, scleromyxedema, nephrogenyc systemic fibrosis, systemic amyloidosis), metabolic diseases (porphyrya cutanea tarda, phenylketonuria, hypothyroidism, scleredema diabeticorum), progeroid syndromes. Given the multiple etiologies of sclerodermal lesions, a correct differential diagnosis is necessary to establish the appropriate treatment.

【 授权许可】

Unknown   
Copyright © 2023 Bobeica, Niculet, Craescu, Parapiru, Corduneanu-Luca, Debita, Pelin, Tiutiuca, Vasile, Nicolescu, Miulescu, Balan and Tatu