Dexmedetomidine and Fentanyl Exhibit Temperature Dependent Effects on Human Respiratory Cilia

Frontiers in Pediatrics

Nils Welchering¹ 

关键词: dexmedetomidine;    ciliary beat frequency;    hypothermia;    human cilia;    fentanyl;    airway cilia motility;   

DOI  :  10.3389/fped.2015.00007

学科分类：儿科学

来源: Frontiers

【 摘 要 】

Background: Dexmedetomidine (dex) is commonly used in intensive care due to its effective sedation and analgesia with few adverse effects and minimal respiratory depression. However, we recently observed that exposing mouse epithelial respiratory cells to dex decreased ciliary beat frequency (CBF), suggesting dex may pose pulmonary risk.

【 授权许可】

CC BY