High-Resolution Melting Curve Analysis, a Rapid and Affordable Method for Mutation Analysis in Childhood Acute Myeloid Leukemia

Frontiers in Pediatrics

Yin Liu¹ 

关键词: FLT3;    NPM1;    MLL;    high-resolution melting curve analysis;    acute myeloid leukemia;    childhood;   

DOI  :  10.3389/fped.2014.00096

学科分类：儿科学

来源: Frontiers

【 摘 要 】

Background: Molecular genetic alterations with prognostic significance have been described in childhood acute myeloid leukemia (AML). The aim of this study was to establish cost-effective techniques to detect mutations of FMS-like tyrosine kinase 3 (FLT3), nucleophosmin 1 (NPM1), and a partial tandem duplication within the mixed-lineage leukemia (MLL-PTD) genes in childhood AML.

【 授权许可】

CC BY