An open treatment trial of duloxetine in elderly patients with dysthymic disorder:

SAGE Open Medicine

NancyKerner¹ 

关键词: Duloxetine;    dysthymic disorder;    elderly;    serotonin-norepinephrine reuptake inhibitor (SNRI);    antidepressant;    depression;   

DOI  :  10.1177/2050312114533536

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Objective:We evaluated the efficacy and side effects of the selective serotonin and norepinephrine reuptake inhibitor antidepressant duloxetine in older adults with dysthymic disorder.Methods:Patients ≥ 60 years old with dysthymic disorder received flexible dose duloxetine 20–120 mg daily in an open-label 12-week trial. The main outcomes were change from baseline to 12 weeks in 24-item Hamilton Depression Rating Scale scores and Treatment Emergent Symptoms Scale scores. Response required ≥ 50% decline in Hamilton Depression Rating Scale scores with a Clinical Global Impression of much improved or better, and remission required final Hamilton Depression Rating Scale ≤ 6. Intent-to-treat analyses were conducted with the last observation carried forward.Results:In 30 patients, the mean age was 70.7 (standard deviation (SD) = 7.6) years and 56.7% were female. In intent-to-treat analyses, there were 16 responders (53.3%) and 10 remitters (33.3%). Of these, 19 patients completed the trial. The mean maximum dose...

【 授权许可】

CC BY