Chromosome aberrations induced by curcumin and aloin in Allium cepa L. root meristem cells

Turkish Journal of Biology

LOGANATHAN PALANIKUMAR¹ 

关键词: Curcumin;    aloin;    clastogenicity;    mitotic index;    Allium cepa L.;   

学科分类：生物科学（综合）

来源: Scientific and Technical Research Council of Turkey - TUBITAK

【 摘 要 】

To date, a variety of plant compounds have been studied extensively with regard to anti-mutagenic, anti-carcinogenic, and anti-genotoxic activity. Nevertheless, very few of them have been studied in terms of clastogenicity. In the present study the clastogenic activity of curcumin (the active component of turmeric) and aloin (the active component of aloe) was evaluated at doses of 5, 10, 20, 30, 50, and 100 µg/mL for 4, 8, and 12 h. Both curcumin and aloin had significant dose- and time-dependent clastogenic effects on the test plant system (Allium cepa L.). Compared to curcumin, aloin was more clastogenic. Clastogenic activity was obvious at very low concentrations of curcumin and aloin at all time points. The mitotic index was significantly lower at higher concentrations; however, the exact mechanism of curcumin and aloin clastogenicity remains unknown in plant test systems.

【 授权许可】

Unknown