A Prospective Study to Investigate Predictors of Relapse among Patients with Opioid Use Disorder Treated with Methadone:

Substance Abuse: Research and Treatment

LeenNaji¹ 

关键词: opioid use disorder;    substance abuse;    methadone;    opioid substitution treatment;    opioid relapse;   

DOI  :  10.4137/SART.S37030

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

IntroductionConcomitant opioid abuse is a serious problem among patients receiving methadone maintenance treatment (MMT) for opioid use disorder. This is an exploratory study that aims to identify predictors of the length of time a patient receiving MMT for opioid use disorder remains abstinent (relapse-free).MethodsData were collected from 250 MMT patients enrolled in addiction treatment clinics across Southern Ontario. The impact of certain clinical and socio-demographic factors on the outcome (time until opioid relapse) was determined using a Cox proportional hazard model.ResultsHistory of injecting drug use behavior (hazard ratio (HR): 2.26, P = 0.042), illicit benzodiazepine consumption (HR: 1.07, P = 0.002), and the age of onset of opioid abuse (HR: 1.10, P < 0.0001) are important indicators of accelerated relapse among MMT patients. Conversely, current age is positively associated with duration of abstinence from illicit opioid use, serving as a protective factor against relapse (HR: 0.93, P = 0.00...

【 授权许可】

CC BY