A Swedish Population-based Study of Adverse Birth Outcomes among Pregnant Women Treated with Buprenorphine or Methadone: Preliminary Findings:

Substance Abuse: Research and Treatment

Keele E.Wurst¹ 

关键词: buprenorphine;    methadone;    opioid agonist medication-assisted treatment;    opioid use disorder;    pregnancy;    opioid dependence;   

DOI  :  10.4137/SART.S38887

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

BackgroundUntreated opioid dependence in pregnant women is associated with adverse birth outcomes. Buprenorphine and methadone are options for opioid agonist medication-assisted treatment during pregnancy.ObjectiveThe aim of this study was to describe adverse birth outcomes observed with buprenorphine or methadone treatment compared to the general population in Sweden.MethodsPregnant women and their corresponding births during 2005–2011 were identified in the Swedish Medical Birth Register. Data on stillbirth, neonatal/infant death, mode of delivery, gestational age at birth, Apgar score, growth outcomes, neonatal abstinence syndrome, and congenital malformations were examined. Frequencies were compared using two-sided Fisher's exact tests. Unadjusted estimates of birth outcomes for women treated with buprenorphine or methadone were compared to the registered general population.ResultsA total of 746,257 pregnancies among 538,178 unique women resulted in 746,485 live births. Among the 194 women treated wit...

【 授权许可】

CC BY