Stem Cells Isolated from the Sheath and Core Tissues of Human Plantar Fascia Exhibit Differential Biological Properties:

Foot & Ankle Orthopaedics

JianyingZhang¹ 

关键词: plantar fascia;    stem cells;    sheath;    core;    mechanical loading;   

DOI  :  10.1177/2473011418S00131

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Category:HindfootIntroduction/Purpose:Plantar fasciitis is a very common ligament disease which affects more than 3 million patients in the United States every year. However, there is no effective treatment in clinics because its pathogenesis is largely unknown. Although PF has been studied quite well from a biomechanical viewpoint, little has been done on PF biology. To better understand the cellular mechanisms of plantar fasciitis, in this study we aimed first to characterize biological properties of stem cells isolated from the sheath and the core of human PF tissues. Their biological responses to mechanical loading are also studied.Methods:Two stem cell populations isolated from the sheath (PF-S) and core (PF-C) parts of human PF tissues were investigated by characterizing their colony formation, stem cell marker expression, population doubling time (PDT), multi-differentiation potentials, and biological responses to mechanical loading. One-way ANOVA followed by Fisher’s PLSD for multiple comparisons ...

【 授权许可】

CC BY