Interferon-g +874A/T Polymorphism Is Associated With Asthma Risk: A Meta-analysis

Journal of Investigational Allergology and Clinical Immunology

Q Xiu¹  X Wang³  L Meng⁴  W Nie² 

[1] Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China;L Meng,;Q Xiu;X Wang,

关键词: Meta-analysis;    Polymorphism;    Asthma;    Interleukin-γ;   

Others  :  1183669

【 摘 要 】

Background: Results regarding the association between the interferon-γ (IFN-γ) +874A/T polymorphism and asthma risk are controversial and ambiguous. The aim of this study was to determine with greater precision the relationship between the IFN-γ +874A/T polymorphism and asthma using a meta-analysis.

Methods: Published literature was retrieved from 5 databases (PubMed, EMBASE, Wanfang, China National Knowledge Infrastructure [CNKI] and Weipu). ORs with 95% CIs were used to assess the strength of association.

Results: Ten case-control studies involving 697 cases and 1049 controls were identified. In the overall analysis, a significant association between the +874A/T polymorphism and asthma susceptibility was found for AA vs AT + TT (OR, 1.89; 95% CI, 1.37-2.62; P=.0001). In the subgroup analysis by ethnicity, significant associations were found among whites (OR, 1.42; 95% CI, 1.04-1.93; P=.03) and Asians (OR, 2.52; 95% CI, 1.49-4.25; P=.0006). The sensitivity analysis and cumulative meta-analysis further strengthened the validity of this association. No publication bias was observed in this study.

Conclusion: The results of this meta-analysis suggest that the IFN-γ +874A/T polymorphism is a risk factor for asthma.