Effects of TNF-α Polymorphisms on Asthma Risk: A Systematic Review and Meta-Analysis

Journal of Investigational Allergology and Clinical Immunology

Q Xiu¹  T Ye²  G Lai⁴  J Chen²  Y Zang²  J Qian³  W Nie²  H Huang² 

[1] Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China;Q Xiu;Y Zang,;T Ye,

关键词: Polymorphism;    Meta-analysis;    Tumor necrosis factor-α;    Asthma;   

Others  :  1183651

【 摘 要 】

Background: Several studies have examined associations between TNF-α polymorphisms and asthma risk, but the results have been conflicting.

Methods: A search was performed of the PubMed, EMBASE, and Wanfang databases. Data were extracted and pooled ORs with 95% CIs were calculated.

Results: Fifty-four studies were included. A significant association between the TNFA -308A/G polymorphism and asthma susceptibility was observed for AA+AG vs GG (OR, 1.39; 95% CI, 1.23-1.58; P<.001). This polymorphism was also significantly associated with asthma risk in whites (OR, 1.47; 95% CI, 1.25-1.73; P<.001), atopic asthma risk (OR, 1.38; 95% CI, 1.16-1.65; P<.001), pediatric asthma risk (OR, 1.48; 95% CI, 1.23-1.79; P<.001), and adult asthma risk (OR, 1.35; 95% CI, 1.21-1.52; P<.001). There was also a significant association between the TNFA -857C/T polymorphism and asthma risk in the recessive model (OR, 1.25; 95% CI, 1.10-1.43; P<.001). In the subgroup analyses, asthma risk was significantly increased in Asians (OR, 1.23; 95% CI, 1.07-1.41; P=.004) and atopic individuals (OR, 1.33; 95% CI, 1.13-1.57; P<.001). No significant association was found for the TNFA -238A/G polymorphism. There were insufficient data to evaluate
the associations between TNFA -1031T/C and -863C/A polymorphisms and asthma risk.

Conclusions: This meta-analysis suggests that TNFA -308A/G and -857C/T polymorphisms are risk factors for asthma.