Genetic diversity among Trypanosoma (Duttonella) vivax strains from Zambia and Ghana, based on cathepsin L-like gene

Parasite

and Chihiro Sugimoto³  Kofi Afakye²  Charles Mahama²  Boniface Namangala⁴  Kyoko Hayashida³  Andy Alhassan²  Ryo Nakao³  Jesca Nakayima¹ 

[1] National Livestock Resources Research Institute (NaLIRRI), P.O. Box 96Tororo,Uganda;Veterinary Services Department, P.O. Box M161Accra,Ghana;Division of Collaboration and Education, Research Center for Zoonosis Control, Hokkaido University, Kita 20, Nishi 10, Kita-ku, Sapporo,Hokkaido001-0020,Japan;Department of Paraclinical Studies, School of Veterinary Medicine, University of Zambia, P.O. Box 32379,Lusaka,Zambia

关键词: Ghana;    Zambia;    Trypanosoma vivax;    Trypanosomiasis;   

Others  :  808571
DOI  :  doi:10.1051/parasite/2013024

 received in 2013-03-27, accepted in 2013-06-18,  发布年份 2013

【 摘 要 】

Understanding the evolutionary relationships of Trypanosoma (Duttonella) vivax genotypes between West Africa and Southern Africa can provide information on the epidemiology and control of trypanosomosis. Cattle blood samples from Zambia and Ghana were screened for T. vivax infection using specie-specific PCR and sequencing analysis. Substantial polymorphism was obtained from phylogenetic analysis of sequences of cathepsin L-like catalytic domains. T. vivax from Ghana clustered together with West African and South American sequences, while T. vivax from Zambia formed one distinct clade and clustered with East African and Southern African sequences. This study suggests existence of distinct genetic diversity between T. vivax genotypes from West Africa and Zambia as per their geographical origins.

【 授权许可】

   
© J. Nakayima et al., published by EDP Sciences, 2013

【 图 表 】

Figure 1.

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