Effect of piroxicam, metamizol, and S-adenosylmethionine in a murine model of experimental trichomoniasis

Parasite

A.R. Martínez-Fernández¹  D. Montero-Pereira¹  J.A. Escario¹  A. Gómez-Barrio¹  J.J. Nogal-Ruiz¹ 

[1] Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense,Madrid,Spain

关键词: S-adenosylmethionine;    metamizol;    piroxicam;    Trichomonas vaginalis;   

Others  :  808814
DOI  :  doi:10.1051/parasite/2005121079

 received in 2004-09-28, accepted in 2004-11-08,  发布年份 2005

【 摘 要 】

Biological effects of piroxicam, metamizol, and S-adenosylmethionine (S-AMET) have been tested in NMRI mice infected intraperitoneally with Trichomonas vaginalis. An intraperitoneal treatment during ten preinfection days with piroxicam (10 mg/Kg/day), or metamizol (275 mg/Kg/day), but not with S-AMET (17 mg/Kg/day) induced a significant decrease of abdominal lesions and mortality, assessed by means of a pathogenicity index. The trichomonicidal activity of piroxicam, metamizol, and S-AMET was tested in vitro at the concentration of 300 μM, but found ineffective. These assays have shown the usefulness of the experimental trichomoniasis model for the study of the immunomodulating activity of synthetic drugs.

【 授权许可】

   
© PRINCEPS Editions, Paris, 2005