Determinação espectrofotométrica de dipirona em produtos farmacêuticos por injeção em fluxo pela geração de íons triiodeto

Química Nova

Airton Vicente Pereira²  Luciane Penckowski²  Marcos Vosgerau²  Michelli Fernanda Sassá²  Orlando Fatibello Filho¹ 

[1] ,Universidade Estadual de Ponta Grossa Setor de Ciências Biológicas e da Saúde Departamento de Ciências Farmacêuticas

关键词: metamizol;    triiodide generation;    flow injection spectrophotometry;    pharmaceutical formulations;   

DOI  :  10.1590/S0100-40422002000400008

来源: SciELO

【 摘 要 】

A flow injection spectrophotometric procedure was developed for the determination of metamizol in pharmaceutical formulations. The system is based on the reaction between metamizol and triiodide generated in the system by mixing iodate and iodide-starch solutions. The absorbance of triiodide-starch complex giving a steady-state baseline value which was monitored at 580 nm. The inverse peaks caused by metamizol samples were measured and there was a direct relationship between absorbance decreasing and metamizol concentration from 1.4 x 10-4 to 7.0 x 10-4 mol L-1. The RSD was 0.45 % for a metamizol solution 4.2 x 10-4 mol L-1 (n = 10) with a detection limit (three-fold blank standard deviation/slope) of 6.0 x 10-5 mol L-1 The feasibility of the system was demonstrated for the determination of metamizol in commercial samples with sixty results obtained per hour. The results obtained for metamizol in pharmaceutical formulations using the proposed flow procedure and those obtained using an iodimetric procedure are in agreement at the 95% confidence level and within an acceptable range of error.

【 授权许可】

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