Serum Tryptase Concentrations in Beekeepers With and Without Hymenoptera Venom Allergy

Journal of Investigational Allergology and Clinical Immunology

A González-Quintela²  M Boquete¹  C Vidal³  R Núñez¹  V Coutinho²  L Vizcaino²  M Alonso²  F Carballada¹ 

[1] Department of Allergy, Hospital Lucus Augusti, Lugo, Spain;Department of Medicine, Hospital Clínico Universitario, Santiago de Compostela, Spain;Department of Allergy, Hospital Clínico Universitario, Santiago de Compostela, Spain

关键词: Venom allergy;    Beekeeper;    Hymenoptera;    Tryptase;   

Others  :  1183840

【 摘 要 】

Background: Increased tryptase concentrations are a risk marker for the severity of reactions to Hymenoptera stings or venom immunotherapy.

Objective: To investigate serum tryptase concentrations in beekeepers with and without Hymenoptera venom allergy (HVA).

Methods: Serum tryptase concentrations were measured in adult patients with HVA (n=91, 37 of whom were beekeepers), beekeepers without HVA (n=152), and control individuals from the general adult population (n=246).

Results: Multivariate analyses revealed that serum tryptase levels were positively associated with beekeeping activities (P<.001) and HVA (P<.001). Tryptase levels were also positively associated with age (P<.001) and male sex (P=.02), and negatively associated with alcohol consumption (P=.002).

Conclusions: Beekeeping and HVA are independently associated with increased concentrations of serum tryptase.