Isradipine – a calcium channel blocker – does not potentiate chloroquine antiplasmodial activity against Plasmodium falciparum

Parasite

and R. Jambou¹  M. Randrianarivelojosia² 

[1] Unité d’Immunologie, Institut Pasteur de Dakar,BP 220,Sénégal;Natural Products Research Group, School of Chemistry, University of KwaZulu-Natal,Durban,4041,South Africa

关键词: Madagascar;    Plasmodium falciparum;    isradipine;    chloroquine;   

Others  :  808793
DOI  :  doi:10.1051/parasite/2005122187

 received in 2005-01-24, accepted in 2005-02-28,  发布年份 2005

【 摘 要 】

Culturing fresh clinical isolates of P. falciparum and using the isotopic method, we tested separately chloroquine and isradipine – a calcium channel blocker –, and also the combination isradipine plus chloroquine. Tested wild isolates were chloroquinesensitive. With regard to the combination isradipine/chloroquine, the isobolograms obtained indicate that isradipine antagonises chloroquine antiplasmodial activity. Taking into account these findings, we discuss the issues related to the calcium channel blocker molecules.

【 授权许可】

   
© PRINCEPS Editions, Paris, 2005