Caution: Reptile pets shuttle grasshopper allergy and asthma into homes

World Allergy Organization Journal

Tamar Kinaciyan⁴  Bruno Robibaro²  Sebastian A.F. Jensen³  Isabella Pali-Schöll¹  Erika Jensen-Jarolim¹ 

[1] Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna, Waehringer G. 18-20, Vienna, 1090, Austria;The Rudolfinerhaus, Vienna, Austria;AllergyCare, Allergy Diagnosis and Study Center, Vienna, 1220, Austria;Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University Vienna, Vienna, Austria

关键词: Allergy;    IgE;    Reptile pets;    Pets;    Asthma;    Reptile;    Grasshopper;   

Others  :  1223842
DOI  :  10.1186/s40413-015-0072-1

 received in 2015-03-26, accepted in 2015-05-29,  发布年份 2015

【 摘 要 】

The numbers of reptiles in homes has at least doubled in the last decade in Europe and the USA. Reptile purchases are increasingly triggered by the attempt to avoid potentially allergenic fur pets like dogs and cats. Consequently, reptiles are today regarded as surrogate pets initiating a closer relationship with the owner than ever previously observed. Reptile pets are mostly fed with insects, especially grasshoppers and/or locusts, which are sources for aggressive airborne allergens, best known from occupational insect breeder allergies. Exposure in homes thus introduces a new form of domestic allergy to grasshoppers and related insects. Accordingly, an 8-year old boy developed severe bronchial hypersensitivity and asthma within 4 months after purchase of a bearded dragon. The reptile was held in the living room and regularly fed with living grasshoppers. In the absence of a serological allergy diagnosis test, an IgE immunoblot on grasshopper extract and prick-to-prick test confirmed specific sensitization to grasshoppers. After 4 years of allergen avoidance, a single respiratory exposure was sufficient to trigger a severe asthma attack again in the patient.

Based on literature review and the clinical example we conclude that reptile keeping is associated with introducing potent insect allergens into home environments. Patient interviews during diagnostic procedure should therefore by default include the question about reptile pets in homes.

【 授权许可】

   
2015 Jensen-Jarolim et al.

【 图 表 】

Fig. 1.

【 参考文献 】

• [1]Shirley SM, Kark S. Amassing efforts against alien invasive species in Europe. PLoS Biol. 2006; 4(8): Article ID e279
• [2]Bacon SJ, Bacher S, Aebi A. Gaps in border controls are related to quarantine alien insect invasions in Europe. PLoS ONE. 2012; 7(10): Article ID e47689
• [3]Banks NC, Paini DR, Bayliss KL, Hodda M. The role of global trade and transport network topology in the human-mediated dispersal of alien species. Ecol Lett. 2015; 18(2):188-199.
• [4]Van Huis A, Van Itterbeeck J, Klunder H, Mertens E, Halloran A, Muir G et al. Edible insects. Future prospects for food and feed security. In: http://www.fao.org/docrep/018/i3253e/i3253e.pdf. Rome. 2013.
• [5]Publication of European Union Association of Reptile Keepers (EUARK). In: http://www.fbh.org.uk/news/downloads/euark_brochure_2012.pdf. UK. 2012.
• [6]Collis A, Fenili M. The Modern U.S. Reptile Industry Publications of the White House, President Barack Obama. In: http://www.whitehouse.gov/sites/default/files/omb/assets/oira_1018/1018_04182011-3.pdf. Georgetown Economic Services, LLC Economic Analysis Group, Jan 5th, 2011
• [7]Saul WC, Jeschke JM. Eco-evolutionary experience in novel species interactions. Ecol Lett. 2015; 18(3):236-245.
• [8]Salmonella-Infektionen bei Säuglingen und Kleinkindern durch Kontakt zu exotischen Reptilien. Epidemiologisches Bulletin. 2013; 9:71-82.
• [9]San Miguel-Moncin MM, Pineda F, Rio C, Alonso R, Tella R, Cistero-Bahima A. Exotic pets are new allergenic sources: allergy to iguana. Curr Opin Allergy Clin Immunol. 2006; 16(3):212-213.
• [10]Blahak S. Tierärztliche Arbeitsgemeinschaft Amphibien und Reptilienkrankheiten, Deutsche Gesellschaft für Herpetologie und Terrarienkunde, Arbeitsgruppe Reptilien und Amphibien in Privathand. Stellungnahme zur Haltung von Reptilien und Amphibien in Privathand in Deutschland. Deutsches Tierärzteblatt. 2009; 11:1468-1476.
• [11]Frankland AW. Locust sensitivity. Annals of Allergy. 1953; 11(4):445-453.
• [12]Von der Bijl WJ. Asthma als Berufskrankheit: Allergie gegen Heuschrecken. Allergie und Asthma (Asthma as an occupational disease: Allergy to grasshoppers). Allerg Asthma 1963; Jul (9):154–5.
• [13]Burge PS, Edge G, O’Brien IM, Harries MG, Hawkins R, Pepys J. Occupational asthma in a research centre breeding locusts. Clinical Allergy. 1980; 10(4):355-363.
• [14]Soparkar GR, Patel PC, Cockcroft DW. Inhalant atopic sensitivity to grasshoppers in research laboratories. Curr Opin Allergy Clin Immunol. 1993; 92(1 Pt 1):61-65.
• [15]Fuchs E. Insects as inhalant allergens. Allergol Immunopathol. 1979; 7(3):227-230.
• [16]Wirtz RA. Allergic and toxic reactions to non-stinging arthropods. Annu Rev Entomol. 1984; 29:47-69.
• [17]Monk BE. Contact urticaria to locusts. The British Journal of Dermatology. 1988; 118(5):707-708.
• [18]Tee RD, Gordon DJ, Hawkins ER, Nunn AJ, Lacey J, Venables KM et al.. Occupational allergy to locusts: an investigation of the sources of the allergen. Curr Opin Allergy Clin Immunol. 1988; 81(3):517-525.
• [19]Lopata AL, Fenemore B, Jeebhay MF, Gade G, Potter PC. Occupational allergy in laboratory workers caused by the African migratory grasshopper Locusta migratoria. Allergy. 2005; 60(2):200-205.
• [20]Harris-Roberts J, Fishwick D, Tate P, Rawbone R, Stagg S, Barber CM et al.. Respiratory symptoms in insect breeders. Occup Med. 2011; 61(5):370-373.
• [21]Semple S, Devakumar D, Fullerton DG, Thorne PS, Metwali N, Costello A et al.. Airborne endotoxin concentrations in homes burning biomass fuel. Environ Health Perspect. 2010; 118(7):988-991.
• [22]Jacobs JH, Krop EJ, Borras-Santos A, Zock JP, Taubel M, Hyvarinnen A et al.. Endotoxin levels in settled airborne dust in European schools: the HITEA school study. Indoor Air. 2014; 24(2):148-157.
• [23]Hammad H, Chieppa M, Perros F, Willart MA, Germain RN, Lambrecht BN. House dust mite allergen induces asthma via toll-like receptor 4 triggering of airway structural cells. Nat Med. 2009; 15(4):410-416.
• [24]Bergner RK. Letter: Misconceptions regarding grasshopper allergy. Pediatrics. 1974; 54(2):255-256.
• [25]Schnitzker WF. Grasshopper allergy. Pediatrics. 1974; 53(2):280-281.
• [26]Lierl MB, Riordan MM, Fischer TJ. Prevalence of insect allergen-specific IgE in allergic asthmatic children in Cincinnati. Ohio Annals of Allergy. 1994; 72(1):45-50.
• [27]Prasad R, Verma SK, Dua R, Kant S, Kushwaha RA, Agarwal SP. A study of skin sensitivity to various allergens by skin prick test in patients of nasobronchial allergy. Lung India : official organ of Indian Chest Society. 2009; 26(3):70-73.
• [28]Baldo BA, Panzani RC. Detection of IgE antibodies to a wide range of insect species in subjects with suspected inhalant allergies to insects. International Archives of Allergy and Applied Immunology. 1988; 85(3):278-287.
• [29]Leung PSC, Chow WK, Duffey S, Kwan HS, Gershwin ME, Chu KH. IgE reactivity against a cross-reactive allergen in crustacea and mollusca: evidence for tropomyosin as the common allergen. Curr Opin Allergy Clin Immunol. 1996; 98(5 Pt 1):954-961.
• [30]Pener MP. Allergy to Locusts and Acridid Grasshoppers: a Review. Journal of Orthoptera Research. 2014; 23(1):59-67.